[Frontiers in Bioscience 12, 4370-4383, May 1, 2007] 4370 Notch signaling and its role in breast cancer
نویسندگان
چکیده
1. Abstract 2. Introduction 3. Notch signaling pathway 3.1. Notch receptors and ligands 3.2. Notch signaling activation 3.3. Notch signaling targets 4. Notch signaling in tumorigenesis 4.1. Cell proliferation 4.2. Cell survival (apoptosis evasion) 4.3. Angiogenesis 4.4. Cell invasion and metastasis 4.5. Notch and viral oncogenes 4.5.1. EBV viral protein EBNA2 and Notch 4.5.2. HPV viral protein E6/E7 and Notch 4.6. A controversial role of Notch in tumorigenesis 4.7. Interplay between Notch signaling and epigenetic silencers in cancer 5. Cross-talk between Notch signaling and other oncogenic pathways in mammary tumor development 5.1. Ras signaling pathway 5.2. ErbB2 signaling pathway 5.3. TGFb signaling pathway 5.4. Wnt signaling pathway 5.5. HIF signaling pathway 6. Notch signaling as a prognosis marker of breast cancer 7. Targeting Notch signaling pathway as potential therapies for breast cancer 8. Notch signaling and cancer stem cells 9. Perspective 10. Acknowledgements 11. References
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